MR-proADM: a biomarker of microcirculatory and endothelial damage.

Mid-regional proadrenomedullin (MR-proADM) is a blood biomarker that is elevated in diseased states in response to the increased hyper-permeability of the microcirculation, and subsequent plasma leakage into the extracellular space. In addition, adrenomedullin has potent vasodilatory properties.

It can be used in both the emergency and intensive care departments to assess the severity of an infection on the host response and the risk of disease progression.